THE EFFECTS OF ADRIAMYCIN ON THE ACTIVITY OF p38 MAPK IN GASTRIC CANCER CELL SGC7901 AND MULTIDRUG RESISTANT CELL SGC7901/VCR
- VernacularTitle:p38信号途径与胃癌细胞阿霉素耐药相关
- Author:
Yutian WANG
;
Jialu HU
;
Lib YAO
- Publication Type:Journal Article
- Keywords:
p38 MAPK pathway;
adriamycin;
stomach cancer;
multidrug resistance
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigatethe relationship between p38 MAPK pathway and multidrug resistance of stomach cancer. The activity of p38 MAP kinase in stomach cancer cell SGC7901 and multidrug resistant cell SGC7901/VCR were examined by immunoprecipition after adriamycin treatment SGC7901 for 0, 2, 15, 30 and SGC7901/VCR for 0, 2, 15, 30, 60 minutes,respectively. The results indicated that adriamycin could activate the activity of p38 MAP kinase in gastric cancer cell SGC7901 with time dependency, but could decrease remarkably the activity of p38 MAP kinase in gastric cancer multidrug resistant cell SGC7901/VCR after adriamycin treatment it for 15 minutes. It suggested that adriamycin could affect the activity of p38 MAPK in gastric cancer cell SGC7901 and multidrug resistant cell SGC7901/VCR.
