The clinical preliminary use of co registration and fusion of positron emission tomography and MR images in Alzheimer disease
- VernacularTitle:MRI与正电子发射体层摄影图像配准和融合技术在Alzhermer病诊断中的初步应用
- Author:
Kuncheng LI
;
Jingwen LIU
;
Xin ZHAO
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Tomography,emission computed;
Image processing, computer assisted;
Alzheimer′s disease
- From:
Chinese Journal of Radiology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily evaluate the diagnostic value of co registration and fusion of positron emission tomography and MR images in Alzheimer disease (AD). Methods Twelve patients with AD (53-83 years) and six normal volunteer (45-71 years) were scanned by positron emission tomography (PET) and MR imaging. The interval between two examination was 1-32 days (average:18 2?11 6 days). The disc and magnetic tape were used to transfer the imaging data to image work station (SGI O 2), then the special software for co registration and fusion: Statistical Parametric Map was used to do automatic co registration between PET and MR images of brain in 3D. Results The findings of PET was completely accorded with the changes of AD in 9 patients (9/12), and accorded with AD, but should be differentiate from other diseases in 3 cases (3/12). According to the measurement of special cerebral structures, MR images could make the diagnosis of AD in 11 patients (11/12), and had no abnormal finding in 1 case. The medial temporal atrophy could be seen on the MR images co registrated with PET in AD patients, on the other hand, PET demonstrated the pink color region of metabolic rate of glucose decreased in temporoparietal lobes of cerebral hemisphere. The similar findings depicted on fusion images as red color region of metabolic rate of glucose decreased in temporoparietal lobes. Conclusion The co registrated images can accurately observe the abnormal findings of PET and MR images, and fix the location of foci depicted by PET, in addition, fusion images increase the contrast of the foci. Analyzing the images of co registration and fusion of PET and MRI can lead to the diagnosis of AD in all the patients.
