GROWTH INHIBITION OF COLORECTAL CANCER BY TGF-? ANTISENSE OLIGODEOXYNUCLEOTIDE AND EGFR ANTISENSE OLIGODEOXYNUCLEOTIDE
- VernacularTitle:TGF?、EGFR反义寡聚核苷酸对大肠癌生长的抑制作用
- Author:
Yong HE
;
Jun ZHOU
;
Jinsheng WU
- Publication Type:Journal Article
- Keywords:
transforming growth factor ?;
epidermal growth factor receptor;
antisense;
colorectal neoplasm@
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of TGF?antisense oligodexynucleotides(ASODN) and EGFR ASODN on human rectal carcinoma cell line HR8348. Cationic liposome, lipofectamine, were selected as delivery vector HR8348 cells were treated with ASODN in vitro. HR8348 cells with or without pretreatment were inoculated into nude mice. The proliferation and DNA synthesis of HR8348 cells treated with TGF-? ASODN and EGFR ASODN were greatly inhibited, and tumorigenic rate was also greatly reduced. TGF-? ASODN and EGFR ASODN could inhibit the proliferation of human colon cancer cell line in vitro as well as in vivo, the results implicate. The potential value in colorectal cancer gene therapy.
