Cerebral Functional Change & Clinical Response in Children with Attention Deficit/Hyperactivity Disorder: Using SPECT Imaging Subtraction Method.
- Author:
Boong Nyun KIM
1
;
Jae Sung LEE
;
Dong Soo LEE
;
Soo Churl CHO
Author Information
1. Department of Psychiatry, Kyoungnam Province Mental Hospital, Sacheon, Korea.
- Publication Type:Original Article
- Keywords:
ADHD;
SPECT image subtraction method;
Change between pre and post-treatment
- MeSH:
Brain;
Caudate Nucleus;
Child*;
Diagnostic and Statistical Manual of Mental Disorders;
Frontal Lobe;
Humans;
Perfusion;
Psychometrics;
Sensitivity and Specificity;
Thalamus;
Tomography, Emission-Computed, Single-Photon*;
Weights and Measures
- From:Journal of Korean Neuropsychiatric Association
1999;38(3):593-603
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We conducted this study to find out topographic change of cerebral perfusion during methylphenidate(abbr: MPH) treatment and to compare between the change of SPECT and clinical improvement in subjects with attention deficit hyperactivity disorder(abbr: ADHD). METHODS: By DSM-IV criteria, we selected 32 pure ADHD patients through various assessment scales, psychometric tools and neuropsychological battery. All the patients were studied by 99m Tc-HMPAO brain SPECT, before MPH treatment and after 6 week treatment. Using image subtraction method, we obtained(+)/(-)NDR parametric image in each patient. RESULTS: When the change of brain SPECT and clinical improvement were compared, matching rate, senstivity and specificity between them were 81.1%, 85.3% and 75.2%. Increased cerebral blood flow in (+)NDR parametric image was found in frontal lobe, caudate nucleus and thalamus, especially in Right hemisphere. CONCLUSION: These findings indicated that MPH improved cerebral blood flow in fronto-caudato-thalamic areas, which have been known as region associated with pathophysiology of ADHD
