Effect of CGRP on L-type calcium channel current in guinea pig single ventricular myocytes on normal, imitating ischemia and hypoxia conditions
- VernacularTitle:CGRP对正常及模拟缺血缺氧状态下豚鼠心肌细胞L型钙通道电流的影响
- Author:
Lijun SHANG
;
Yimin ZANG
;
Weiji ZANG
- Publication Type:Journal Article
- Keywords:
CGRP;
ischemia;
hypoxia;
cardiomyocytes;
L-type calcium curreX
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of CGRP on L-type calcium channel current in guinea pig ventricular myocytes under normal and imitating ischemia and hypoxia conditions. METHOD The whole-cell patch clamp recording technique was used. RESULTS When the ventricular cell was held at -40 mV and depolarized to 0 mV, 1?10 -9 、1?10 -8 and 1?10 -7 mol?L -1 CGRP increased I Ca-L from(1 26?0 18)nA ( n =8) to (1 87?0 25)nA ( P
