Prolongation of human polymorphonuclear leukocyte function by IL-1?
- VernacularTitle:白细胞介素1?对多形核白细胞功能的促进作用
- Author:
Min SHI
;
Shuguang WU
- Publication Type:Journal Article
- Keywords:
polymorphonuclear leukocyte;
interleukin 1?;
apoptosis;
spreading;
polarization;
phagocytosis;
superoxide anion
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM Interleukin 1?(IL-1?), which is a pivotal cytokine in inflammatory response, can inhibit human polymorphonuclear leukocyte (PMN) apoptosis,which can enhance PMN-mediated cytoxicity. Therefore we research the effect of IL-1? on the change of PMN functions was studied. METHODS Functional capacity of PMN was assessed by spreading, polarization (shape change), superoxide anion production and phagocytosis. RESULTS IL-1? can prolong PMN function by the inhibition of PMN apoptosis. CONCLUSION IL-1? inhibits PMN apoptosis, resulting in a larger population of surviving PMN with a greater capacity for phagocytosis and superoxide production. The later potentially facilitates PMN mediated tissue injury and may be one of mechanisms by which IL-1? contributes to organ dysfunction.
