Antitumor effects of curcumin combining with adriamycin in vitro
- VernacularTitle:姜黄素与阿霉素联合用药的体外抗肿瘤作用
- Author:
Xi LIN
;
Jianhua XU
;
Danru KE
- Publication Type:Journal Article
- Keywords:
curcumin;
adriamycin;
synergistic effect;
antitumor activ
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate antitumor effects of curcumin (Cur) combining with adriamycin(ADM) on human tumor cell lines in vitro . METHODS The antitumor effects of the drugs on tumor cell lines in vitro were determined with MTT method. The Jin's formula was used to analyse the effect of drug combination. RESULTS In simultaneous adiministration Cur 2 04 ?mol?L -1 ～16 29 ?mol?L -1 combining with ADM 0 70 ?mol?L -1 ～5 52 ?mol?L -1 produced a simple addition or potentiation effect. In sequential adiministration the first adiministration of ADM followed by Cur resulted in an antagonistic effect, while the change of the order of adiministration produced an simple addition effect. CONCLUSION Simultaneous adiministration of Cur and ADM produces synergistic effect but sequential adimistration of the drugs only produce a unidirectional synergistic effect.
