Studies of icariin and pseudomonas jinanensis agent on anti-metastatic mechanism in vitro
- VernacularTitle:淫羊藿苷及济南假单胞菌制剂联合应用体外抗转移的研究
- Author:
Haiting MAO
;
Ling ZHANG
;
Yun WANG
;
Xiaobing LI
- Publication Type:Journal Article
- Keywords:
icariin;
pseudomonas jinanensis agent;
PG cell;
adhesion;
invasion;
metastasis;
enhanced effec
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM Mechanism of icariin (ICA) and pseudomonas jinanensis agent (PJA) on anti-metasta-sis of a highly metastatic human lung tumor cell line (PG) and the effect type of the combination of ICA,PJA were studied. METHODS PG cells were treated with ICA、PJA, or the combination of both in vitro. Adhesion assay, invasion assay, migration assay, flow cytometry (FCM) and immunohistochemical straining were used. The effects of ICA and PJA combination were evaluated with Q method of Jin Zheng-Jun. RESULTS ICA、PJA could decrease PG cells adhesive ratio to laminin substrate in a time-dependent manner ( P
