Influence of pulmonary metastasis of three bisdioxopiperazines on Lewis lung carcinomas in vivo
- VernacularTitle:三个哌嗪二酮类化合物对Lewis癌体内肺转移的影响
- Author:
Dayong LU
;
Fugen WU
;
Jingyi CAO
;
Lu GONG
;
Bi XU
- Publication Type:Journal Article
- Keywords:
probimane;
bimolane;
razoxane;
neoplasm metastasis;
antineoplastic agents;
cancer chemotherapy
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To compare the effects of probimane( Pro), bimolane ( Bim) and razoxane( Raz) on animal tumor metastasis in vivo . METHODS A biological inoculation method for assessment of pulmonary metastasis of Lewis lung carcinoma(3LL) was employed. RESULTS Pro and Bim inhibited the pulmonary metastasis of 3LL both from d 2 and from d 8 injections, but Raz only inhibited the pulmonary metastasis of 3LL from d 2 injections. Pro inhibited the pulmonary metastasis of 3LL more potently than Bim did at equitoxic dosage. CONCLUSION Pro is better in the treatment of pulmonary metastasis of 3LL than Raz for its possible novel molecular mechanisms.
