Effect of nimodipine on apoptosis induced by cerebral ischemia
- VernacularTitle:尼莫地平对大鼠缺血后脑细胞凋亡的影响
- Author:
Qiaoer CHEN
;
Zhiwu CHEN
;
Chuangeng MA
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
nimodipine;
apoptosis
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the inhibitory effect of nimodipine on apoptosis induced by cerebral ischemia. METHODS Incomplete cerebral ischemia was made by ligating bilateral common carotid arteries(CCA) in rats. The apoptosis was determined by terminal deoxy-nucleotidyl transforase-mediated dUTP-digoxigenin nick end-labeling(Tunel) method. The DNA fragmentation analysis was measured with the diphenylamine reagent method. RESULTS Ligting of bilateral CCA markedly produced apoptotic cell in cerebral cortex. Nim 2 mg?kg -1 significantly decreased the numbers of apoptotic cells in cortex; Nim 1 mg?kg -1 , 2 mg?kg -1 also inhibited the increase of DNA fragmentation induced by cerebral ischemia. CONCLUSION Nim has inhibitory effect on ischemia-induced apoptosis of cerebral cortex.
