Effects of ginsenoside of stem and leaf in combination with choline on improving learning and memory of Alzheimers disease
- VernacularTitle:人参茎叶皂苷和胆碱协同改善Alzheimer病学习记忆的作用
- Author:
Xiaomin ZHAO
;
Ruiyi ZONG
;
Xianglin XIE
;
Chengyu LU
- Publication Type:Journal Article
- Keywords:
ginsenoside of stem and leaf;
choline;
Alzheimers disease;
learning and memory
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the synergical effects of ginsenoside of stem and leaf(GSL)in combination with choline on learning and memory of Alzheimers disease(AD). MEHODS AD animal models were made by damaging nucleus basalis of Meynert with quinolinic acid. One time training passive aviodance step-down and water-maze spatial localization task were used to observe the ability of learning and memory.RESULTS Treatment with combination of GSL(400 mg?kg -1 ?d -1 ,ig) and choline(200 mg?kg -1 ?d -1 ,ig) on AD rats decreased significantly the number of errors on step down (ig for 13 days) and the training times to reach the criterion on water maze (ig for 16 days). The effect of GSL in combination with choline was more remarkable than that of GSL or choline and proved no obvious difference compaired with that of 1,2,3,4-tetrahydroacridine (10 mg?kg -1 ?d -1 ,ig). Value Q was more than one after administrition of both GSL and choline. CONCLUSION GSL in combination with choline may synergically improve the impairement of learning and memory of AD.
