Effect of roxithromycin on pharmacokinetics of aminophylline at steady state
- VernacularTitle:罗红霉素对兔体内稳态时氨茶碱药代动力学的影响
- Author:
Chunping TANG
;
Tao JIANG
;
Huaihai ZHOU
;
Xuemei SU
;
Qizhang DU
- Publication Type:Journal Article
- Keywords:
aminophylline;
roxithromycin;
pharmacokinetics;
interaction;
HPLC
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effect of oral roxithromycin on serum concentrations at steady state and its pharmacokinetics of aminophylline in New Zealand rabbits. METHODS The experiment was divided into 2 stages: (Ⅰ) The subjects only received a four-day course of oral aminophylline until steady-state; (Ⅱ) aminophylline and roxithromycin were coadministrated from the d 5～10. After the last dose of aminophylline at the end of each study stage, serum theophylline concentrations were determined with HPLC. RESULTS Compared to stage Ⅰ, AUC、CL/Fs、 K a、 K e、 T 1/2(ka) 、 T max had significantly changed or very significantly changed at stage Ⅱ ( P
