Expression and significance of COX-2 in pilosebaceous unit
- VernacularTitle:环氧合酶-2在毛囊皮脂腺单位的表达及其意义
- Author:
Yuanxu XU
- Publication Type:Journal Article
- Keywords:
cyclooxygenase-2;
hair follicle;
sebaceous gland;
stem cell
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression pattern of COX-2 in adult rat pilosebaceous unit.Methods The expression pattern of COX-2 was detected by RT-PCT,immunohistochemical staining and stem cell primary culture.Results COX-2 expression in pilosebaceous unit of adult rat showed strongly positive at sebaceous gland,positive in bulge region and negative in hair matrix.Conclusion COX-2 in adult rat sebaceous gland was strongly and specifically expressed.Based on the theory that the hair follicle stem cells can migrate and differentiate from bulge region to sebaceous gland,the expression patterns of COX-2 indicates that it may play an important role on orienting differentiation of hair follicle stem cells to sebocytes.
