Correlation of substance P nerve fiber and mast cells in hypertrophic scar
- VernacularTitle:增生性瘢痕中P物质神经纤维与肥大细胞关联的形态学观察
- Author:
Liang CHEN
- Publication Type:Journal Article
- Keywords:
hypertrophic scar;
substance P;
mast cell
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the morphology of substance P nerve fiber and mast cells in hypertrophic scar and normal skin and investigate the interaction of substance P nerve fiber and mast cells in hypertrophic scar.Methods The hypertropic scar tissue and the normal skin was from 8 burnt patients who underwent operation owing to cicatricial contracture.The amount and shape of substance P nerve fiber and mast cells in hypertrophic scar were observed after immunohistochemistry and toluidine blue.Results In hypertropic scar tissue,the substance P nerve fiber was ramous and interlacing,but in normal skin,it was paralleled.The mast cells in the hypertropic scar tissue(7.22) were more than that in normal skin(4.64).Substance P and mast cells showed close relationship in hypertrophic scar,as pearls' appearance that was more significant than in normal skin.Conclusion Substance P and mast cells have close relationship in hypertrophic scar,indicating that substance P and mast cells may play an important role in the development and pruritus of hypertrophic scar.
