The study of cytopathogenic effect of hemorrhagic fever with renal syndrome virus on renal tubular cells
- VernacularTitle:肾综合征出血热病毒对肾小管上皮细胞损伤的研究
- Author:
Lijun YAO
;
Anguo DENG
;
Pei HUANG
- Publication Type:Journal Article
- Keywords:
Hemorrhagic fever;
Renal syndrome;
Renal tubular cells;
Hemorrhagic fever virus
- From:
Chinese Journal of Nephrology
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cytopathogenic effect of epidemic hemorrhagic fever with renal syndrome virus (HFRSV) on renal tubular cells(RTC). Methods Human fetal renal tubular cells (HFRTC) were cultured in vitro. HFRTC infected or not infected by HFRSV were observed by using trypan-blue stain and transmission electron microscopy(TEM). Viral-mRNA was detected by in situ molecular hybridization. Results (1) HFRSV could directly infected HFRTC: (2)The death rate of HFRTC in the infection group was significantly higher than that in the control grou 1 to 4 weeks after infection; (3) Injuries of cell membrane and cell organs after infection with HFRSV were significantly earlier and more severe as compared to control by means of TEM. Conclusion HFRSV can directly damage renal tubular cells (RTC ), which contributes to the pathogenesis of hemorrhagic fever with renal syndrome (HFRS).
