Protective effects of losartan on diabetic glomerulopathy in STZ-induced diabetic rats
- VernacularTitle:氯沙坦对糖尿病大鼠肾脏保护作用的探讨
- Author:
Xiaohua LU
;
Lie FENG
;
Minhua XU
- Publication Type:Journal Article
- Keywords:
Diabetic glomerulopathy;
Nitric oxide;
Endothelin;
Transforming growth factor-?;
Losartan
- From:
Chinese Journal of Nephrology
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objndve To evaluate the protective effects of specific antagonists of angiotensin II receptor losartan on the kidneys of diabetic rats and study their mechanisms. Methods Changes of urinary albumin, ?2-m excretion, creatinine clearance(Ccr), NO, ET level of plasma, urine and renal tissue, serum and urinary TGF-?1 concentration and mean glomerular volume were measured. Results Losartan could correct elevated urinary albumin, ?2-m excretion, Ccr and mean glomerular volume. Urinary and renal tissue NO, ET concentration decreased after diabetic rats received losartan. Large doses of losartan also reduced urinary TGF-?1 level. Conclusion Losartan can protect the kidney of diabetic rats and the decrease of NO, ET, TGF-?1 concentration in renal tissue may be a mechanism for this action.
