Role of type I plasminogen activator inhibitor in mediating renal tubulointerstitial injury of patients with IgA nephropathy
- VernacularTitle:Ⅰ型纤溶酶原激活物抑制物在IgA肾病肾小管间质损伤中的作用研究
- Author:
Jianzhong WANG
;
Xiangmei CHEN
;
Suozhu SHI
- Publication Type:Journal Article
- Keywords:
IgA nephropathy;
Renal tubule;
Renal interstitium;
Plasminogen activator inhibitor type- I
- From:
Chinese Journal of Nephrology
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of type 1 plasminogen activator inhibitor (PAI-1 ) in mediating renal tubulointerstitial injury of patients with IgA nephropathy. Methods The mRNA and protein production of PAI-l in renal tubulointerstitium were defected using in stiu hybridization and immunohistochemistry. Detections of antigens of ?-smooth muscle actin(?-SMA) and proliferating cell nucleus antigen (PCNA) were also performed. Results PAI-l was normally expressed in the walls of vessels and distal tubules, but significantly increased in lesions of IgA nephropathy, including crescents, Bowman capsules and tubulointerstitial infiltrating cells. There was lithe expression of PAl-1 in the glomerular capillary tufts. The renal expression of PAI-l was significantly correlated with serum creatinine (P
