EXPRESSION OF SV40 LARGE TUMOR ANTIGEN AND FORMATION OF COMPLEXES WITH P53 AND PRb IN HUMAN BRAIN TUMORS
- VernacularTitle:人脑肿瘤中猴病毒40大T抗原的表达及与P53、PRb特异性复合物的形成
- Author:
Xiang ZHANG
;
Haining ZHEN
;
Zho FEI
- Publication Type:Journal Article
- Keywords:
polyomavirus, macacae;
brain neoplasms;
protein P53
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
SV40 large tumor antigen(Tag) expression was investigated by immunoprecipitation followed by silver staining and Western blot in 65 cases of human brain tumors and 8 cases of normal brain tissues, Tag P53 and Tag PRb complexes were screened respectively in 18 and 15 Tag positive tumor tissues. SV40 Tag was found in ependymomas, choroid plexus papillomas, pituitary adenomas, astrocytomas, meningiomas, glioblastomas multiforme and medulloblastomas, whereas 8 normal brain tissues were all negative for Tag. Tag P53 and Tag PRb complexs were detected respectively in Tag positive tumors. The results indicated that SV40 is associated with human brain tumori genesis, and the in activation of P53 and PRb due to the formation of Tag P53 and Tag PRb complexes is possibly an important mechanism in the etiopathogenesis of human brain tumors.
