MECHANISM OF PATHOGENETIC ROLE OF ALDOSTERONE IN DEVELOPMENT OF MYOCARDIAL FIBROSIS IN SHR
- VernacularTitle:醛固酮致自发性高血压大鼠心肌纤维化的作用机制
- Author:
Xiaohua XIE
;
Chaoshu TANG
;
Shiwen WANG
- Publication Type:Journal Article
- Keywords:
hypertension;
myocardial fibrosis;
aldosterone;
spironolactone
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the mechanism of aldosterone in the induction of hypertensive myocardial fibrosis, we compared the changes of the incorporation rate of 3H proline, the contents of cardiac tissue collagen, and the activities of the cardiac mitogen activated protein kinase (MAPK) in the spontaneous hypertensive rats (SHRs) untreated and treated with a competitive antagonist of the aldosterone receptorspironolactone (spiron), and also in normotensive rats. The results showed that the incorporation of 3H proline incubating with the myocardial tissue slices significantly increased at three time points (at 4,6,8 h), that the tissue collagen contents and the activities of tissue MAPK also increased in SHRs than in SHRs treated with spiron and in normotensive rats. It suggests that aldosterone stimulates the cardiac MAPK through specific recepter, thus increases the absorption of proline and synthesis of collagen in the cardiac fibroblasts, and in turn, is responsible for the myocardial fibrosis.
