Effects of aspirin on promoter activities of human MMP-9 gene
- VernacularTitle:阿司匹林对基质金属蛋白酶9启动子活性的影响
- Author:
Yong QI
- Publication Type:Journal Article
- Keywords:
MMP-9;
DU145;
promoter;
aspirin;
transcriptional regulation
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). CAT expression of pCAT 1.28 and pCAT 0.65 are 2 and 1.6 times as high as the control group's. CAT expression of pCAT 1.28, pCAT 0.65 and pCAT 0.54 were 2.5, 2.2 and 1.3 times as high as the control group's. Aspirin inhibited the promoter activities of pCAT 1.28, pCAT 0.65. And the inhibition of Aspirin was reversed by PMA. CONGCLUSION:Aspirin can inhibit the expression of human MMP-9 gene in the transcriptional level and can inhibit the formation and development of prostatic carcinoma.
