Effect of colchicine on the changes of serum activity of tumour necrosis factor in rabbits with endotoxic shock
- VernacularTitle:兔内毒素休克模型中秋水仙碱对血清肿瘤坏死因子活性的影响
- Author:
Wu NI
;
Mingxing ZHOU
;
Guojun WANG
- Publication Type:Journal Article
- Keywords:
Colchicine Lipopolysaccharides Tumor necrosis factor
- From:
Chinese Journal of Infectious Diseases
1999;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to determine the effect of colchicine(Col) on the changes of serum activity of tumour necrosis factor (TNF) induced by lipopolysaccharide(LPS) in rabbits.Methods Twelve New Zealand white rabbits were equally divided into 2 groups, namely group A and group B. Rabbits in group A were intravenously administered with 0.2ml/ kg of normal saline (NS) from 67h before LPS inje ction, while those in group B were given 0.5mg/ kg of Col instead of NS at the same time course.Endotoxic shock was induced by intravevous injection of 2?g/ kg of LPS after the challenge by Bacillus Calmette Gu?rin(BCG). Results Prior infusion of Col significantly decreased the peak levels of serum TNF activity ( P
