Development of leukotriene B_4 research
- VernacularTitle:白三烯B_4研究进展
- Author:
Ran LIU
;
Baohua MA
;
Jin XU
- Publication Type:Journal Article
- Keywords:
leukotriene B4;
arachidonic acid;
inflammation;
immune regulation;
cytokines
- From:
Chinese Pharmacological Bulletin
1998;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Leukotriene B4 is a small metabolite of phospholipid in membrane through PLA2,5-LO, LTA4 hydrolase and other related enzymes. It is been synthesized in almost all kinds of tissue cells, then transported to outside of the cells, which may be separated from its synthesis. LTB4 shows complex bioactivities, especially in inflam-mation, immune system and plays an important role. Its functions are mediated by its different receptors on the membrane. Also, LTB4 interacts with other cytokines, and they form a network regulating functions of the body.
