Role of adhesion molecules in neutrophil-mediated inflammation
- VernacularTitle:中性粒细胞介导炎症与粘附分子之间的关系
- Author:
Yanan FANG
;
Gengtao LIU
- Publication Type:Journal Article
- Keywords:
adhesion molecules;
neutrophil;
endothelial;
inflammation;
selectins;
integrins;
immunoglobulin superfamily
- From:
Chinese Pharmacological Bulletin
1998;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Adhesion molecules are involved in neutrophil-mediated inflammation. Neutropil adhesion to endothelial cell mediated by cell adhesion molecules (CAMs) is the first and critical step during the process of inflammation. Three families of CAMs play a central role in neutrophil-endothe-lial cell interactions : the selectins, the integrins, and the immunoglobulin superfamily. These different types of CAMs interact in a programmed, sequential manner to form neutrophil-endothelial cell adhesion cascade. The initial phase of inflammation, neulrophil slowing and rolling, is mediated by selectins; subsequently, firm adhesion of neu-trophils to vessel endothelial cells occurs via binding of the activated integrins and the endothelial receptors such as intercellular adhesion molecule-1 (ICAM-1); Then, neutrophils transmigrate into the tissues, this process requires chemotactic factors, integrins and PEC AM-1. Because of the important role of CAMs in the process of inflammation. Agents may be used to block the function of CAMs as a strategy of antiinflammatory therapy.
