Intracellular modulation and its mechanisms of GABA_A receptors
- VernacularTitle:GABA_A受体的细胞内调控及其机制
- Author:
Zhiping PANG
;
Tianle XU
;
Jishuo LI
- Publication Type:Journal Article
- Keywords:
GABAA receptors;
Ca2+;
adenosine triphosphate (ATP);
protein kinase A;
protein kinase C;
tyrosine kinase
- From:
Chinese Pharmacological Bulletin
1998;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
In addition to modulation by a variety of structurally diverse agents that act allosteri-cally via distinct binding sites on the receptor complexes , there is another outstanding characteristic of the GABAA receptors: they are modulated by multiple endogenous agents. Well known examples include Ca2+ , adenosine triphosphate (ATP) , protein kinase A (PKA), protein kinase C(PKC), ty-ros ine kinase (TK) and calmodulin-dependent protein kinase II (CaMK II ). Intracellular modulation of GABAA receptor function may have profound effects on the control of neuronal excitation.
