Study on the relationship between HLA-DR gene and lupus nephritis
- VernacularTitle:人类白细胞抗原DR基因与狼疮性肾炎相关性的探讨
- Author:
Min WANG
;
Yi DONG
;
Yon ZHAO
- Publication Type:Journal Article
- Keywords:
HLA-DR antigens PCR-SSP Lupus nephritis
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the HLA-DR gene frequency in systemic lupus erythematosus (SLE) patients and its relationship with renal involvement and AN As profile. Mefliods HLA-DRB1 genotype frequency assigned by PCR amplification with sequences-specific primers (PCR-SSP) in 89 Chinese patients with SLE and 106 ethnically and geographically matched controls. Results HLA-DR2 and DR9 were significantly more frequent in SLE patient group (0.36/0.20, RR= 2.36, P
