Study on gene expression of PTH/PTHrP receptor in patients with renal impairment
- VernacularTitle:肾脏病患者甲状旁腺素受体基因表达的研究
- Author:
Jian ZHANG
;
Jing CHEN
;
Weiyu ZHU
- Publication Type:Journal Article
- Keywords:
Parathyroid hormone receptor Gene expression Renal disease
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of parathyroid hormone receptor in patients with different stages of renal disease and its possible underlying mechanisms. Methods Relatively quantitative RT/PCR method was used to detect PTH receptor mRNA expression in renal specimens obtained through biopsy or operation. Results The levels of PTH receptor mRNA were significantly decreased in all patients with chronic glomerulonephritisx moderate renal failure severe renal failure and acute renal failure, which was correlated with the extent of renal impairment. Conclusion The downregulation of renal PTH receptor occurs much earlier than the changes of renal function., plasma PTH., serum phosphate and calcium in the course of human renal disease.
