The titer of ANCA in relation to disease activity in patients with microscopic potyarteritis
- VernacularTitle:抗中性粒细胞胞浆抗体滴度检测对微型多动脉炎肾损害活动性的诊断价值
- Author:
Kai SUN
;
Leishi LI
- Publication Type:Journal Article
- Keywords:
Anti-neutriphil cytoplasmic antibodies Tiler Microscopic polyarteritis Disease activity
- From:
Chinese Journal of Nephrology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether ANCA liter is sensitive serological marker reflecting vasculitis disease activity. Methods MPO-ANCA and IF-ANCA tilers variation in five sera specimen with active MPA diseases were studied after methylprednisolone and cyclophosphamide pulse therapy. The clinical and pathological features of 5 patients with MPA were investigeted comparing pre-treatment with post-treatment. Results (1) Serum ANCA were found positive and increased liter in 5 patients wilh active MPA disease. (2) Titer decreased after Ireatment, while renal function improved. (3) After half year, MPO-ANCA was negative in 5 patients, IF-ANCA was negative in 2 patients. Conclusion There is a close correlation between serum ANCA titer and MPA renal disease activity.
