Comparison of the protective effect of circulating TNF-?removal between immunoadsorption and Amberlite XAD-7 absorption on endotoxin shock
- VernacularTitle:免疫吸附与大孔树脂吸附清除循环TNF-?对内毒素休克保护作用的比较
- Author:
Bin TANG
;
Hongai ZHUO
;
Xun ZHANG
- Publication Type:Journal Article
- Keywords:
Endotoxin shock Tumor necrosis factor Immunoadsorption Amberlite XAD-7
- From:
Chinese Journal of Nephrology
1997;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To estimate the protective effect of removing circulatory TNF-a immunoadsorpnon or Amberlite XAD-7 absorption respectively on endotoxin shock. Methods New Zealand white rabbits injected with lethal dose of endotoxin underwent hemoper-fusion through immunoadsorbent or Amberh'te XAD-7 respectively. Plasma TNF-a levels were detected, and the sorbent efficiency and survival rate were observed. Results After 2 hours hemoperfusion through immunoadsorbent or Amberlite XAD-7 respectively, plasma TNF levels were significandy lower than those in die control group, especially, die sorbent efficiency of immunoadsorp-tion was higher dian dial of Amberlite XAD-7 adsorption. Conclusion Compared widi die nonspecific Amberlite XAD-7 adsorption, immunoadsorption might be a specific and more effective therapy of endotoxin shock.
