Re-evaluation of serum and urinary soluble interieukin 2 receptors in diagnosis of acute renal allograft rejection
- VernacularTitle:重新评估可溶性白介素2受体检测诊断移植肾急性排异的意义
- Publication Type:Journal Article
- Keywords: Soluble intedeukin 2 receptor Renal allograft Acute rejection
- From: Chinese Journal of Nephrology 1997;0(05):-
- CountryChina
- Language:Chinese
- Abstract: To re-evaluation of serum and urinary soluble interleukin 2 receptors (sIL-2R) in diagnosis of acute renal allo-graft rejection. Methods A group of renal transplant patients were observed for serum and urinary sIL-2R level with sandwich enzyme immunoassay. Hie expression of IL-2R in tissue sections of renal graft of these cases biopsied at the same time were also investigated. Results sIL-2R levels in serum and urine were significantly higher in groups with rejection and infection compared with no rejection and controls. IL-2R values measured in all intrarenal samples were found to be consistently higher during rejection than in nonrejection conditions. Conclusion (1) Acute rejection group as a whole (in average) showed a much higher level of both serum and urinary sIL-2R. But single measurement of sIL-2R was influenced by many factors such as urinary output, fever and renal function. It can not be relied for the diagnosis of rejection, unless serial assays were made. (2) Expression of IL-2R in renal tissue is a more reliable marker for acute rejection.