Interrelationships between plasma renin activity, aldosterone, atrial natriuretic peptide and blood volume in adult nephrotic syndrome
- VernacularTitle:成人原发性肾病综合征血容量与肾素、醛固酮、心钠素的关系
- Author:
Qing ZHONG
;
Dadao LI
;
Ren LIANG
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome Blood volume Plasma renin activity Aldosterone Atrial natriuretic peptide
- From:
Chinese Journal of Nephrology
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the interrelationship between plasma renin activity(PRAXaldosterone (Ald),atrial natri-uretic peptide ( ANP ) and blood volume ( BV ) in adult nephrotic syndrome ( NS ) . Methods BV was assessed using 113mInCl dilution method. PRA、 Angiotensin Ⅱ (AngⅡ)、Ald、ANP were determined by radioirnmunoassay. 28 edema-tous NS patients,26 healthy controls and 18 cases of remission were involved. Results (1)During edematous period, PR, AngⅡ , Ald、 ANP were higher in NS than in controls. There was no difference of BV between NS and controls. Albumin ,PRA,AngⅡ 、Ald and ANP were not correlated with BV; (2)After remission, comparing with edematous period, Ald 、ANP deceased significantly whereas PRA、AngⅡ、Ald and total BV were not different; (3) Urine natrium excretion (UNaV) was negatively correlated with Aid. Conclusion Ald and ANP may be the major regulating factors of sodium excretion in nephrotic syndrome.
