Comparison of growth and apoptosis of fibroblasts derived from kidneys with and without interstitial fibnwis
- VernacularTitle:有与无间质纤维化肾组织培养的成纤维细胞生长及凋亡比较
- Author:
Guoqiang ZHENG
;
Rengao YE
;
Yongxinng CHENG
- Publication Type:Journal Article
- Keywords:
Fibrosis Renal interstitium Fibroblast Apoptosis
- From:
Chinese Journal of Nephrology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of fibroblasts in the pathomechanisms of renal interstitial fibrosis(RIF). Methods Growth behavior and apoptos, of renal interstitial fibroblasts in cultures, established using renal biopsies of casts with and without RIF, were studied. Results There were significant alterations in the growth behavior, the differentiation pattern of potentially mitotic fibroblast populations and programmed cell death in cultures derived from kidneys with RIF, as compared with cultures of normal origin. Conclusion The abnormal growth and apoptosis of fibroblasts may play an im-portant role in RIF. Inhibiting the proliferation and promoting the programmed death of fibroblasts may be benificial to patients with RIF.
