The inflammatory cell infiltration and ICAM-1 expressing in renal tissue of immununointerstitial model
- VernacularTitle:免疫性间质性肾炎动物模型肾组织炎症细胞浸润与细胞间粘附分子-1的表达
- Author:
Jiangmin FENG
;
Jingchuan WU
;
Xijing ZHOU
- Publication Type:Journal Article
- Keywords:
Interstitial nephritis Cellular immunity Monoclonal antibody ICAM
- From:
Chinese Journal of Nephrology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of immunointerstitial nephritis. Methods BN rat model was obtained with bovine tubular base membrane (bTBM). Monoclonal antibodies, immunohistochemical ABC method and indirect im-munofluorescent technique were used to detect the inflammatory cells and ICAM-1. Results 9 days after immunization with bTBM, inflammatory cells infiltration and a strong ICAM-1 expression were found in the intersitium, associated with the pathological degree. Conclusion Cellular immunity mediated by ICAM-1 may play an important role in the development of immunointerstitial nephritis. Macrophage is a leading factor among various inflammatory cells. Fluid immunity can not be excluded.
