Changes of sexual hormones and sexual hormone receptors in the patients with chronic glomerulonephritis and uremia
- VernacularTitle:慢性肾炎及尿毒症患者性激素及性激素受体改变的研究
- Publication Type:Journal Article
- Keywords: Andrpgen receptor Estrogen receptor Chronic glomenllonephritis Uremia
- From: Chinese Journal of Nephrology 1994;0(02):-
- CountryChina
- Language:Chinese
- Abstract: Objective Whether changes of sexual hormones and sexual hormone receptors were involved in the pathogeny of chronic glomerulonephritis and uremia. Methods The maximal binding capacity (Bmax)' and dissociation constant (Kd) of androgen receptor (AR) and estrogen receptor (ER) in the peripheral leukocytes were estimated by radioligand binding assays in 63 patients with chronic glomerulonephritis and 101 with uremia. Results (1)The Bmax of AR was 638? 176, 508 ? 112 and 437? 126 sites/cell in men, child-bearing age womeru menopause women with chronic nephritis re-spectivily. The binding capacity was not different with controls. (2)The Bmax of ER was 1041?358, 1492 ? 387 and 1107 ? 274 sites/cell in three groups of chronic nephritis .respectively. They were all higher than those of controls ( P 1298? 413 and 10381284 sites/cell in three groups of uremia respectively. The binding capacity of ER was all higher than that of controls ( P