A technique for long- term intravenous infusion in rats
- VernacularTitle:大鼠长期静脉输液技术
- Author:
Xiaoting WU
- Publication Type:Journal Article
- Keywords:
Rat Intravenous infusion Parenteral nutrition
- From:
Parenteral & Enteral Nutrition
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to develop a technique which provides not only a route for continuous intravenous administration of drugs,but easy access for TPN support in unrestrained rats as well,we designed a fluid infusion swivel system with implanting and maintaining venous catheter in the superior vena cava of rats,and administered a long- term intravenous infusion in unrestrained rats. The results showed that the average period for which infusion was carried out was 1 0 days,and the infusion was maintained for up to 3week in some of rats.All animals appeared to tolerate infusion catheter without obvious discomfort and minimal restriction of their motion.Kinking and leakage did not occur anymore.We conclude thatthis technique can be readily utilized and has great potential value for studying problems related to surgical nutrition and metabolism.
