Thermal injury induces some protooncogenes expression in wounded skin tissue
- VernacularTitle:热损伤诱导创面组织C-myc、C-myb、C-sis和C-jun原癌基因的表达
- Author:
Yulin CHEN
;
Duo WEI
;
Weirong YU
;
Shengde GE
- Publication Type:Journal Article
- Keywords:
burn;
protooncogene;
dot blot hybridization
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the expression of some protooncogenes in burn wounded skin tissue. Methods: The protooncogene expression was analysed by mRNA dot blot hybridization,autoradiography and densitermeter. Results: Thermal injury induced C-myc, C-myb, C-jun and C-sis mRNA expression. How-ever, those four protooncogenes showed different expression models. Expression of C-myc and C-jun in-creased at d 1, and peaked 1 and 3 d postburn, respectively. Expression of C-myb and C-sis increased 3and 5 d, and peaked 10 d after thermal injury. Conclusion: Thermal injury can induce some protooncogeneexpression which sh0wed temporal order and well controlled manifestation. Those results suggest thatthose four protooncogenes are involved with the repair process as a regulator.
