Effects of controlled reperfusion of warm blood cardioplegia on reducing myocardial ischemia/reperfusion injury in cat heart
- VernacularTitle:温血停搏液控制性再灌注减轻缺血心肌再灌注损伤的实验研究
- Author:
Long CHEN
;
Shoupeng HU
;
Rongliang ZHANG
;
Baoren ZHANG
;
Jialin ZHU
;
Rukun CHEN
;
Keming CHEN
;
Lin YANG
- Publication Type:Journal Article
- Keywords:
myocardial ischemia;
reperfusion injury;
myocardial function;
AFP;
cardiopulmonary bypass
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
To test the hypothesis that the controlled reperfusion of warm blood cardioplegiacontaining mannitol would result in more effectively improved recovery of myocardial function by prevent-ing or reducing a potentially harmful component of reperfusion. Methods: Thirty-two cats were divided in-to four groups. Group Ⅰwas not subjected to ischemia or reperfusion injury. Group Ⅱ was subjected to60 min hypothermic ischemia. Group Ⅲwas subjected to 60 min hypothermic ischemia and 60 min reperfu-sion. Group Ⅳ was controlled reperfusion with warm blood cardioplegia containing mannitol. Results:Myocardial functlon was significantly depressed after 60 min reperfusion- Increased myocardial water con-tent and low ATP c0ntent were observed also. Controlled reperfusion with warm bl0od cardioplegia con-taining mannitol was helpful to improve the recovery of myocardial function and ATP content, and to re-duce the myocardial water content. Conclusion: These results indicate that controlled reperfusion after is-chemia provides benefit in avoiding myocardium from reperfusion injury.
