The effects of silymarin on the inhibition of nonenzymatic glycation and oxidation in aorta of streptozocin-induced diabetic rats
- VernacularTitle:水飞蓟素对糖尿病大鼠主动脉非酶糖化及氧化的抑制作用
- Author:
Xiangjin XU
;
Jiaqing ZHANG
;
Qingling HUANG
- Publication Type:Journal Article
- Keywords:
silymarin;
aminoguanidine;
diabetes mellitus;
nonenzymatic glycation;
glycoxidation
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the inhibitory effects of silymarin on diabetic blood vessels chroniccomplication. Methods:Silymarin was given to streptozocin-induced diabetic rats. Rats were killed 9 weeksafter treatment. Plasma LPO, fructosamine and RBC-SOD were measured. LPO, fruct0samine, fluores-cence intensities of AGEs, pentosidine and liperperoxide adducts in aorta were also measured. Results:The early nonenzymatic glycation products-fructosamine were not inhibited, however, LPO and f1uores-cence intensities of AGEs, pentosidine,MDA and HNE adducts in aorta were more significantly reducedthan DM group. Conclusion: The results suggest that silymarin may inhibit nonenzymatic glycation andoxidation in aorta of streptozocin-induced diabetic rats and control the diabetic chronic complication.
