INDUCTION OF PROTECTIVE IMMUNITY OF SCHISTOSOMA JAPONICUM RECOMBINANT ANTIGENS IN MICE
- VernacularTitle:日本血吸虫重组抗原保护性免疫力的诱导
- Author:
Dingwen SHEN
- Publication Type:Journal Article
- Keywords:
Schistosoma japonicum, recombinant antigens, protective immunity
- From:
Chinese Journal of Schistosomiasis Control
1992;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
Schistosoma japonicum recombinant antigens were used to immunize mice in order to ob-serve their protective immunity against challenge. It was assumed that the recombinant anti-gens could reduce worm burden (29. 2%- 51. 0%) and inibit the fecundity of female schisto-some (52. 1% - 74. 3%). The antibody titers increased significant 3 weeks after the first im-munization and remained high lever. The results indicated that the recombinant antigens ex-pressed in the E. coli could induce protective immunity against challenge. It might be pro-duced in large scale as an important candidate component of a multivalent vaccine against schistosomiasis japonicum.
