Comparison of pharmacological effects of tetramethylpyrazine and deuterated tetramethylpyrazines
- VernacularTitle:氘代川芎嗪与川芎嗪药理作用比较(一)抗血栓及抗血小板作用
- Author:
Guohui JIANG
;
Shizhen WANG
;
Ji JIANG
- Publication Type:Journal Article
- Keywords:
tetramethylpyrazine ( TMP );
deuterated TMPs;
antithrombosis;
platelet ag-gregation;
isotope effect
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
TMP. The results suggested that 12D-TMP and 6D-TMP possessed remarkable isotope effects, and that the pyrazine ring of TMP may be responsible for its pharmacodynamics, while the substituted groups might primarily govern its pharma-cokinetics and toxicity. The results also indicated that to study the structure activity relationship of TMP and to modify its chemical structure are very fruitful for the development of TMP analogues of high potency.
