Experimental research of anti-inflammatory action and immunoregulation on rabbit's brain phospholipids
- VernacularTitle:兔脑磷脂的抗炎与免疫调节作用
- Author:
Er GAO
;
Huazhou LI
;
Qian YUE
- Publication Type:Journal Article
- Keywords:
animal phospholipids;
antiin-flammatory action;
macrophage;
carbon particle clearance;
hemolysin antibody;
lymphocyte pro-liferation
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Rabbit's brain phospholipids (RBP) 100~200 mg ?kg-1 ip or sc showed anti-inflammatory action on four kind of acute inflammatory animal models. Cephalin and Lecithin were the effective component of antiin-flammatory action on the acute inflammatory animal model. But RBP did not show antiinflam-matory action on the chronic proliferative inflammatory model. RBP increased blood carbon particle clearance, perfaneal macrophage phagocytosis and enhanced lymphocyte proliferation,hemolysin antibody in normal and immunode-pression animal. RBP increased the cGMP content in the liver tissue of immunodepression animal, 0. 1~1 mg ?L-1 RBP promoted proliferation but 100 mg ?L-1 RBP inhibited proliferation induced by PHA in vitro on human lymphocyte.
