Effects of ranitidine on spontaneous beating and action potential of cultured mycardial cells of neonatal rats
- VernacularTitle:雷尼替丁对体外培养乳鼠心肌细胞自发性搏动及动作电位的影响
- Author:
Yuhong YANG
;
Weixin WANG
- Publication Type:Journal Article
- Keywords:
cultured cells;
myocardium;
histamine;
ranitide;
spontaneous beating;
iso-prenaline;
action potentials
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of ranitidine (Ran) on cultured myocardial cells of neonatal rats were observed. Ran 100 ?mol?L-1 took no effect on spontaneous beating rates of cultured myocardial cells, but it decreased the beating rates increased by histamine 10 ?mol?L-1 and did not inhibit the beating rates increased by isoprenaline 2?mol?L-1. Histamine 10?mol?L-1 increased the amplitude, maximal rate of rise and pro-longed action potential duration at 50% (APD50) and 90% (APD90) repolarization. The effect was abolished by Ran 100?mol?L-1. The results suggested that Ran may possess antiarrhythmic action induced by histamine's increase.
