Naloxone can reverse blunted baroreflex sensitivity after acute myocardial infarction
- VernacularTitle:纳络酮可逆转急性心肌梗塞的压力反射钝化
- Author:
Ben HE
;
Daosheng ZHENG
;
Yixian WU
- Publication Type:Journal Article
- Keywords:
naloxone;
acute myocardial in-farction;
baroreflex sensitivity
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute myocardial infarction (AMI) model was made in SD rats by coronary ligation, the effects of naloxone (Nal) on the baroreflex sensitivity (BRS) were evaluated by administrated Nal intravenously (iv) and in-tracisternally (ic) before and after 1 h of AMI.Results showed that both pre and post AMI can Nal potentiate the BRS whether iv or ic. These results indicate that Nal may reverse the blunted BRS after AMI.
