Reactivity of artery rings both with and without endothelium to NE and Ach
- VernacularTitle:高血压左室肥厚大鼠血管内皮的去留对NE和Ach反应的研究
- Author:
Zhuying GUO
;
Manren RAO
- Publication Type:Journal Article
- Keywords:
medipine;
nifedipine;
endotheli-um;
left ventricular hypertrophy
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Renovascular hypertensive rats were treated with either medipine (m-Nif) or nifedipine (Nif) for 9 weeks. In all groups the antihypertive therapies significantly reduced both mean arterial blood pressure and left ventricular hypertrophy. In LVH rats contractions caused by NE were increased on rings both with endothelium and without endothelium, and NE-ratio was greater than 1. The increase in NE induced contraction and the decrease in Ach induced relaxation in LVH rats were due to bothendothelium and smooth muscle dysfuction. In the m-Nif and Nif treated groups, these NE-ra-tio were significantly decreased and had lower maxtimal response and higher IC50. These indicate m-Nif and Nif had direct effect on smooth muscle and endothelium. Our results show that m-Nif and Nif has no influence on the endotheli-um-dependent relaxation to Ach.
