Treatment of 135 patients with malignant astrocytoma
- VernacularTitle:治疗135例脑恶性星形细胞瘤的探讨
- Author:
Yu LI
;
Qihe TIAN
;
Fentong WU
- Publication Type:Journal Article
- Keywords:
Malignant astrocytoma Carotid artery intubation Radiotherapy
- From:
Chinese Journal of Radiation Oncology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To analyze the treatment effects by radiotherapy alone and radiotherapy plus chemotherapy of carotid artery intubation after operation for malignant astrocytoma. Materials and Methods: 135 patients with malignant astrocytoma were treated from August, 1987 to November, 1992. Patients were divided into two groups after operation: 71 patients received radiotherapy alone and 64 patients,combination therapy of chemotherapy (BCNU) plus radiotherapy. All patients received DT 55～70Gy. In combination therapy group, BCNU(250mg) was given daily by carotid artery intubation for 4～15 days.Radiotherapy was given 10～15 days after chemotherapy, then followed by 1～3 intubation. Results: The median survival were 17.5 months in radiotherapy alone group and 31.9 months in combination one.Patients with glioblastoma gave the better results with the 2-,3-,and 5- year survivals of 70%, 36% and 15%, respectively. Conclusion: Chemotherapy (BCNU) of intubation plus radiotherapy is preferable in treating malignant astrocytoma after operation.
