Inhibitory Effects of Imperatorin and Iso-imperatorin on Tumor Necrosis Factor Release from Mouse Peritoneal Macrophages
- VernacularTitle:欧芹素乙和异欧芹素乙对小鼠腹腔巨噬细胞体外释放肿瘤坏死因子的抑制作用
- Author:
Yang JI
;
Guoqian ZENG
;
Yaocheng RUI
- Publication Type:Journal Article
- Keywords:
tumor necrosis factor, peritoneal macrophages, imperatorin, iso-imperatorin, mice
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of imperatorin (Imp) and iso-imperatorin(Isi) on tumor necrosis factor (TNF) release from mouse peritoneal macrophages were investigated. It was found that Imp and lsi significantly inhibited TNF release from mouse peritoneal macrophages. At the concentration of 10-6～10-4 mol?L-1, the inhibitory effects were presented by Imp and Isi in a dose dependent manner. At 10-4 mol/L TNF release was entirely inhibited by each drug.
