DNA — anti — DNA IMMUNE COMPLEXES ENHANCE IL— 6 PRODUCTION BY MOUSE MESANQIAL CELLS
- VernacularTitle:DNA抗DNA免疫复合物促进肾小球系膜细胞产生白介素6
- Author:
Yongxiong CHEN
;
Dan WANG
;
Rengao YE
- Publication Type:Journal Article
- Keywords:
DNA—anti—DNA immune complex;
Interleukin 6;
Mesangial cell
- From:
Chinese Journal of Nephrology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Using the IL—6 dependent hybridoma cell line KD83, we investigated the relationship between KNA—anti—DNA immune complexes(DNA—anti—DNAICs)from the sera of lupus nephritis patients and interleukin 6 (IL—6) production by mouse glomerular mesangial cells cultured in vitro. The results show that DNA—anti—DNA IgM and DNA—anti—DNA IgG and DNA—anti—DNA IgM all enhance IL—6 production by mesangial cells; of those DNA—anti—DNA IC, the effect of DNA—anti—DNA IgM on IL—6 production by mesangial cells was significant. This enhanced production of IL—6 by mesangial cells was dependent on concentration of DAN—anti—DNA ICs.
