SELF— REGULATION OF MESANGIAL CELLS (MsC) PROLIFERATION BY MsC — DERIVED
- VernacularTitle:肾小球系膜细胞产生的白介素1及前列腺素E_2对该细胞增殖的自身调节
- Author:
Yipu CHEN
;
Jin GAO
;
Zhihui ZHAO
- Publication Type:Journal Article
- Keywords:
Mesangial cell;
IL—1;
PGE2
- From:
Chinese Journal of Nephrology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to investigate whether there is an antagonistic effect of MsC—derived IL—1 and PGE2 on MsC proliferation. Experimental results showed that: (1)MsC stimulated by LPS could produce IL—1; (2) MsC stimulated by MsC—derived IL—1 could release PGE2; (3) exogenous PGE2(100ug/ml) inhibited the MsC proliferation induced by MsC—derived IL—1; (4) indomethacin(2ug/ml) which inhibited the production of endogenous PGE2, enhanced the MsC proliferation induced by MsC—derived IL—1. The results suggest that there is a self—regulation effect on MsC proliferation by MsC—derived IL—1 and PGE2. Clinically, the beneficial effect of PGE2 should be protected, so that the abuse of indomethacin in the treatment of glomerulonephritis should be avoided.
