The creation and study of an inherited congenital cataract model in rats
- VernacularTitle:先天性遗传性白内障动物模型建立的实验研究
- Author:
Genlin LI
- Publication Type:Journal Article
- Keywords:
Cataract/congenital;
Models,genetic;
Animals,laboratory;
Lens;
Teratogens
- From:
Ophthalmology in China
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
We used the teratogen 5-hromodeoxy- uridine(BRDU)in the creation of a model of inherited congenital cataract in Wistar rats.The highest rate of impregnation(81%) of the rats was observed during the period oestrus.The frequency of occurrence and the density of the congenital cataract in the F1 generation varied with the dosage of BRDU,and the frequency of the cataract in the F2 generation was positively correla- ted with the dosage of the drug.The crea- tion of this inherited congenital cataract model may be useful in exploring the etio- logy of the cataract and its prevention and treatment.
