A Preliminary Study on Increased Superoxide Anion Release from Murine Macrophages in Response to Recombinant Human Interferon-? and Tumour Necrosis Factor
- VernacularTitle:重组干扰素?及肿瘤坏死因子增强巨噬细胞产生超氧阴离子的初步研究
- Author:
Bingrong ZHOU
;
Ping DU
;
Binghua JIAO
- Publication Type:Journal Article
- Keywords:
interferon ?;
tumour necrosis factor;
superoxide anion;
macrophage
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Superoxide anion releasing from activated murine macrophages stimulated with recombinant human interferon-? (IFN-?), tumour necrosis factor-? (TNF-?) and bacterial lipopolysaccharidc were studied. The results showed that both of the cytokines enhanced superoxide anion release in a dose and time - dependent manner, but lipopolysaccharide had no such an effect as compared with IFN-? and TNF-?. It was also shown that O2- generation from macrophages was highly enhanced after primed with IFN-? or TNF-? for 24 hours. It was concluded from these data that cytokines released from macrophages and lymphocytes during inflammatory reactions could promote O2- generation which may play a crucial role in destruction or kill of intracellular pathogenic bacteria, and tumour cells.
