Experimental Study on the Protection of Cordyceps Sinensis to Cydosporine A Nephrotoxicity
- VernacularTitle:冬虫夏草对大鼠小剂量环孢素A慢性肾毒性保护作用的实验研究
- Author:
Xuezhi ZHAO
;
Leishi LI
- Publication Type:Journal Article
- Keywords:
cyclosporine A;
cordyceps sinensis;
chronic nephrotoxicity;
hemodynamics;
animals;
rats
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to further explore the protective effect of Cordyceps Sinensis (CS) on Cyclosponne A nephrotoxicity (CsA-Nx) and its possible mechanisms, SD rats were divided into two groups: CsA group and CsA + CS group. The results showed that: in different experiment period, serum BUN. Cr, Na. K and urine EOF excretion in CS group were lower than that in control group. In the third month, serum AT- |J in CS group was also lower than that in control group. Pathological examination showed that CS could protect the kidney from CsA-Nx and ameliorate the glomerular and interstitial injuries. It suggests that CS could protect the kidney from CsA-Nx, especially protect the proximal tubular function and ameliorate renal hemodynamics.
